Three former employees and collaborators close to the process said Moderna was always toiling away on new delivery technologies in hopes of hitting on something safer than what it had. And that lack of specificity has inevitably raised questions. Last month, Bancel told Forbes about another new technology, N1GL.īut in neither case has the company provided any details. The company did disclose a new technology on Monday that it says will more safely deliver mRNA. The indefinite delay on the Crigler-Najjar project signals persistent and troubling safety concerns for any mRNA treatment that needs to be delivered in multiple doses, covering almost everything that isn’t a vaccine, former employees and collaborators said. Several major pharmaceutical companies have tried and abandoned the idea, struggling to get mRNA into cells without triggering nasty side effects.īancel has repeatedly promised that Moderna’s new therapies will change the world, but the company has refused to publish any data on its mRNA vehicles, sparking skepticism from some scientists and a chiding from the editors of Nature. The company’s premise: Using custom-built strands of messenger RNA, known as mRNA, it aims to turn the body’s cells into ad hoc drug factories, compelling them to produce the proteins needed to treat a wide variety of diseases.īut mRNA is a tricky technology. In need of a Hail Maryįounded in 2012, Moderna reached unicorn status - a $1 billion valuation - in just two years, faster than Uber, Dropbox, and Lyft, according to CB Insights.
When STAT asked Bancel after the presentation about Crigler-Najjar, he deferred to Alexion. Bancel clicked through graphs of data from animal studies before hurrying on to tout Moderna’s balance sheet and discuss the company’s cancer vaccines, slated for clinical testing later this year. His presentation instead focused on four vaccines that the company is moving through the first phase of clinical trials: two target strains of influenza, a third is for Zika virus, and the fourth remains a secret.
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